PEG衍生物與蛋白藥物修飾和PEG材料介紹

    藥物的聚乙二醇修飾即聚乙二醇化,是將活化的聚乙二醇通過(guò)化學(xué)方法偶聯(lián)到蛋白、多肽、小分子有機(jī)藥物和脂質(zhì)體上是一種蛋白質(zhì)工程分子修飾方法。藥物的聚乙二醇修飾可分為兩個(gè)階段。 
    *階段的修飾技術(shù)局限于應(yīng)用相對(duì)分子質(zhì)量低的單甲氧基聚乙二醇(<20000)。常用的修飾劑有單甲氧基聚乙二醇琥珀酸琥珀酰亞胺酯(mPEG-SS)、單甲氧基聚乙二醇碳酸琥珀酰亞胺酯(mPEG-SC)等,通過(guò)酯鍵或三嗪環(huán)將聚乙二醇與藥物分子偶聯(lián),這種非特異性的不穩(wěn)定連接方式使得一個(gè)藥物分子經(jīng)常連接數(shù)個(gè)聚乙二醇分子。但*代聚乙二醇修飾藥物通常表現(xiàn)出不穩(wěn)定性、較大的毒性和免疫原性,生物活性、藥代動(dòng)力學(xué)的性質(zhì)與原型藥物沒(méi)有本質(zhì)的改變。 
以應(yīng)用相對(duì)分子質(zhì)量高(>20000)聚乙二醇修飾劑為特征的第二階段的修飾技術(shù)具有連接穩(wěn)定、定點(diǎn)修飾、控釋等特點(diǎn),修飾后的藥物具有更高的生物活性、更好的物理及熱穩(wěn)定性、更高的產(chǎn)品均一性和純度。 
但總得說(shuō)來(lái),蛋白藥物PEG修飾技術(shù)中zui大的問(wèn)題就是無(wú)法實(shí)現(xiàn)定點(diǎn)修飾,修飾產(chǎn)物不均一,給分離純化帶來(lái)很大難度,也很大程度上阻礙了臨床應(yīng)用。根據(jù)蛋白質(zhì)的氨基酸性質(zhì)和PEG衍生物的特點(diǎn),科研人員開(kāi)發(fā)了多種定點(diǎn)修飾的策略和方法。
 有一些蛋白的N端對(duì)其生物活性起著重要作用,如果在N端實(shí)施PEG修飾則會(huì)使蛋白的生物活性喪失,因此將PEG修飾的位點(diǎn)轉(zhuǎn)移至C端則是一種有效的修飾策略。一般選用mPEG-酰肼或mPEG-胺對(duì)蛋白質(zhì)進(jìn)行修飾,羧基的修飾位點(diǎn)包括天冬氨酸、谷氨酸及末端羧基。mPEG-酰肼是近年來(lái)開(kāi)發(fā)的又一種可與羧基特異性結(jié)合的修飾劑。
 與賴氨酸相比,半胱氨酸在蛋白質(zhì)中出現(xiàn)幾率和數(shù)量很少,利用具有巰基反應(yīng)活性PEG衍生物就可以實(shí)現(xiàn)蛋白定點(diǎn)修飾,但缺點(diǎn)是半胱氨酸的巰基通常處于蛋白的活性中心,修飾后會(huì)使蛋白活性損失較大。對(duì)于沒(méi)有半胱氨酸的蛋白則可以通過(guò)基因工程手段引入巰基反應(yīng)位點(diǎn)。這一方法不但能夠?qū)崿F(xiàn)高度選擇性修飾,而且能夠減少蛋白生物活性的喪失,并降低免疫原性。  目前可用于巰基修飾的mPEGs包括mPEG-馬來(lái)酰亞胺、mPEG-乙烯基砜及mPEG-碘乙酰胺等。其中mPEG-馬來(lái)酰亞胺制備簡(jiǎn)單,應(yīng)用較多。PEG-鄰吡啶-與蛋白質(zhì)偶聯(lián)形成的S—S鍵,在生理?xiàng)l件下可緩慢水解,釋放出天然蛋白質(zhì),有利于活性的恢復(fù),但修飾率低。PEG-乙烯基砜在pH7-9范圍內(nèi)可選擇性的與巰基反應(yīng),當(dāng)pH較高時(shí)則與氨基交聯(lián)。PEG-碘乙酰胺的優(yōu)勢(shì)在于經(jīng)強(qiáng)酸水解后,可釋放出半胱氨酸衍生物,易于鑒定。
 對(duì)蛋白中含有的二硫鍵進(jìn)行PEG定點(diǎn)修飾分為2個(gè)步驟:首先利用溫和的還原劑使二硫鍵還原釋放兩個(gè)硫氫基;第二步通過(guò)PEG修飾劑的雙烷基化反應(yīng)重建二硫鍵,從而完成PEG的定點(diǎn)修飾。在修飾蛋白過(guò)程中不會(huì)出現(xiàn)蛋白的不可逆變性,而且二硫鍵還原后蛋白仍維持其三級(jí)結(jié)構(gòu),PEG選擇性的修飾兩個(gè)硫基,PEG的立體屏障作用確保1個(gè)二硫鍵只結(jié)合1分子PEG。但是二硫鍵PEG修飾可能會(huì)由于PEG的屏蔽作用,降低蛋白的生物活性。Veronese等利用變性劑鹽酸胍(3mol/L)使蛋白部分變性,結(jié)構(gòu)打開(kāi),但不使用還原劑以保護(hù)二硫鍵,在非折疊狀態(tài)下完成PEG修飾后,通過(guò)透析或凝膠過(guò)濾色譜的方法去除變性劑,使蛋白重新正確折疊恢復(fù)生物活性通常只有具有極性的氨基酸殘基的側(cè)鏈基團(tuán)才能夠進(jìn)行PEG化學(xué)修飾。Deiters等開(kāi)發(fā)了一種定點(diǎn)修飾非極性氨基酸苯丙氨酸的方法,首先用疊氮化物通過(guò)親核取代反應(yīng)修飾蛋白質(zhì)中的苯丙氨酸生成對(duì)位疊氮化苯丙氨酸,再用炔烴衍生的PEG-酰胺修飾劑修飾苯丙氨酸,發(fā)生環(huán)化加成反應(yīng)形成穩(wěn)定的連接體,從而完成對(duì)蛋白的定點(diǎn)修飾。另外,通過(guò)基因重組在蛋白質(zhì)中引入含疊氮基團(tuán)的氨基酸殘基,再與特定PEG修飾劑偶聯(lián)形成穩(wěn)定的定點(diǎn)單修飾產(chǎn)物。Cazalis通過(guò)基因工程方法在血栓調(diào)節(jié)蛋白(Thrombomodulin)的C端引入疊氮蛋氨酸,與mPEG2三芳基膦(mPEG2triarylphosphine)修飾劑生成穩(wěn)定的單修飾物,盡管該方法比較復(fù)雜,但至少給我們提供了一個(gè)新的PEG修飾蛋白的思路
 此類PEG定點(diǎn)修飾的原理是:首先用葡萄糖氧化酶或高磺酸鈉氧化糖類殘基產(chǎn)生具有反應(yīng)活性的醛基,這些醛基可與mPEG2肼衍生物反應(yīng)生成腙或與mPEG2胺衍生物反應(yīng)生成可逆的Schiff堿。用硼氫甲腈鈉可將腙還原為更穩(wěn)定的烷基肼化物,而Schiff堿可以還原為仲胺。相對(duì)于mPEG-胺衍生物修飾,PEG-肼衍生物修飾不會(huì)形成交聯(lián)聚合體,更適合于糖基的修飾,zui有代表性的mPEG2肼衍生物是mPEG2酰肼(hydrazide2mPEG)。酰肼基團(tuán)極低的pKa值使得酰肼基團(tuán)在酸性環(huán)境下(pH4.5～5.0)中仍可以和羧基結(jié)合,而蛋白質(zhì)中的氨基在該條件下由于發(fā)生質(zhì)子化而不能與羧基反應(yīng),從而可實(shí)現(xiàn)選擇性定位修飾。 
由于蛋白種類多樣和結(jié)構(gòu)復(fù)雜,往往會(huì)使得PEG修飾反應(yīng)特異性不強(qiáng),反應(yīng)條件要通過(guò)大量試驗(yàn)優(yōu)化。如果能夠利用計(jì)算機(jī)技術(shù)對(duì)蛋白質(zhì)晶體結(jié)構(gòu)表面性質(zhì)進(jìn)行理論計(jì)算和分析,確定可能的反應(yīng)位點(diǎn)和基團(tuán),并根據(jù)被修飾基團(tuán)與修飾劑的結(jié)構(gòu)特點(diǎn)設(shè)計(jì)合適的連接物,這樣不但可以減少PEG修飾的盲目性,而且能夠提高研究效率。胡遠(yuǎn)東等利用InsightⅡ分子模擬軟件包(BiosymInc.,SanDiego,CA)對(duì)牛血紅蛋白晶體(bHb)進(jìn)行了結(jié)構(gòu)分析和分子模擬,計(jì)算了蛋白表面24個(gè)可進(jìn)行PEG修飾的Lys殘基及其主要原子的溶劑可及表面積,確定了其中可以進(jìn)行修飾的13個(gè)Lys殘基(溶劑可及表面積>0.4nm2),并進(jìn)一步設(shè)計(jì)了具有雙功能基團(tuán)的小分子化合物環(huán)氧乙烷基活化PEG作為連接體。結(jié)果表明,PEG修飾的bHb的攜氧能力和免疫原性等生物學(xué)指標(biāo)均達(dá)到預(yù)期結(jié)果。

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PEG衍生試劑材料的介紹：
我公司聚乙二醇衍生試劑其中PEG可修飾的基團(tuán)包括以下：
PEG-OH 羥基
PEG-NHS 活化脂
PEG-SG  琥珀酰亞胺戊二酸酯   Succinimidyl Glutarate
PEG-MAL 馬來(lái)酰亞胺
PEG-SH  巰基
PEG-Silane  硅烷
PEG-NH2  氨基
PEG-Biotin  生物素
PEG-SS   琥珀酰亞胺琥珀酸酯   Succinimidyl Succinate
PEG-GAS
PEG-ALD  丙醛
PEG-NPC  對(duì)硝基苯碳酸酯
PEG-OPSS 鄰二硫吡啶
PEG-Hydrazide 酰井
PEG-Acrylate 甲氧基-聚乙二醇-丙烯酸酯
PEG-Azide   疊氮
PEG-Alkyne  炔基
PEG-CHO    醛基
PEG-DSPE   二硬脂酸磷脂酰乙醇胺
PEG-FITC   異硫氰酸熒光素
PEG-RB   羅丹明B  
PEG-Chloride  氯化物
PEG-COOH   羧基
PEG-EPO
PEG-SVA  琥珀酰亞胺戊酸酯
PEG-SPA  琥珀酰亞胺丙酸酸酯
PEG-DBCO
PEG-LA  硫辛酸
PEG-膽固醇
PEG-Folic Acid  葉酸
mPEG L-Lysine 賴氨酸
mPEG Cysteine  半胱氨酸
mPEG Glutathione 谷胱甘肽     
mPEG Aspartic Acid 天（門）冬氨酸
mPEG Glutamic Acid
Polylysine PEG
Dextran PEG
BSA PEG Conjugate
 
聚乙二醇修飾產(chǎn)品的詳細(xì)產(chǎn)品列表介紹：
氨基產(chǎn)品目錄表：
mPEG-NHS, MW:2000    
mPEG-CHO, MW:350      
mPEG-NPC, MW:550   
mPEG-PFP, MW:1000      
mPEG-S-S-NHS, MW:3400  
mPEG-SPA, MW:5000      
mPEG-SVA, MW:750       
NHS-PEG-NHS, MW:10000  
NHS-PEG-MAL, MW:5000      
NHS-PEG-Biotin, MW:2000     
NHS-PEG-FITC, MW:5000      
NHS-PEG-Silane, MW:20000        
Diethoxylsilane-PEG-NHS, MW:5000
Monoethoxylsilane-PEG-NHS, MW:5000
NHS-PEG-DSPE, MW:2000     
NHS-PEG-CLS, MW:1000  
NHS-PEG-COOH, MW:3400  
NHS-PEG-OH                      
CHO-PEG-CHO, MW:550     
NPC-PEG-NPC, MW:1000    
mPEG-EPO, MW:20000               
EPO-PEG-EPO, MW:1000         
mPEG-ISC, MW:40000                  
mPEG-ITC. MW:2000                  
ISC-PEG-ISC, MW:3400   
mPEG-Tosylate, MW:5000            
 

巰基產(chǎn)品目錄表：
Maleimide PEG, mPEG-MAL, MW:2000
Maleimide PEG Maleimide, MAL-PEG-MAL, MW:1000
Maleimide PEG NHS, MAL-PEG-NHS, MW:750
Maleimide PEG PFP, MAL-PEG-PFP, MW:3400
Maleimide PEG Biotin, MAL-PEG-Biotin, MW:5000
Maleimide PEG Fluorescein, MAL-PEG-FITC, MW:1000
Maleimide PEG Silane, MAL-PEG-Silane, MW:3400
Maleimide PEG Amine, MAL-PEG-NH2, MW:2000
Maleimide PEG Acid, MAL-PEG-COOH, MW:10000
Ortho-pyridine disulfide PEG, mPEG-OPSS, MW:750
OPSS-PEG-OPSS, MW:1000
OPSS-PEG-NHS, MW:2000
OPSS-PEG-Biotin, MW:2000
OPSS-PEG-NH2, MW:3400
OPSS-PEG-COOH, MW:550
Iodoacetyl PEG, mPEG-IA, MW:20000
Iodoacetyl PEG NHS, IA-PEG-NHS, MW:5000
Iodoacetyl PEG Maleimide, IA-PEG-MAL, MW:2000
Iodoacetyl PEG amine, IA-PEG-NH2, MW:3400
Iodoacetyl PEG Biotin, IA-PEG-Biotin, MW:1000
Iodoacetyl PEG Acid, IA-PEG-COOH, MW:5000
PEG di-iodoacetate, IA-PEG-IA, MW:3400
Vinylsulfone PEG, mPEG-VS, MW:2000
Vinylsulfone PEG acid, VS-PEG-COOH, MW:1000
Vinylsulfone PEG Fluorescein, VS-PEG-FITC, MW:5000
Vinylsulfone PEG Biotin, VS-PEG-Biotin, MW:20000
Vinylsulfone PEG DSPE, VS-PEG-DSPE, MW:550
Vinylsulfone PEG Silane, VS-PEG-Silane, MW:3400
 

Monofunctional PEGs產(chǎn)品目錄表：
Methoxyl PEG, mPEG-OH
Amino PEG, Methoxy PEG Amine, mPEG-NH2
Carboxylic PEG acid, mPEG-COOH
Thiol PEG, methoxy PEG Thiol, mPEG-SH
Azido PEG, mPEG-N3
Hydrazide PEG, mPEG-HAZ
Acrylate PEG, mPEG-ACR
Succinimidyl PEG NHS, mPEG-NHS(SC)
Succinimidyl propionic acid PEG NHS, mPEG-SPA
Succinimidyl valeric acid PEG NHS, mPEG-SVA
Methoxyl PEG Aldehyde, mPEG-CH2CHO
PEG Nitrophenyl Carbonate PEG, mPEG-NPC
Epoxide PEG, mPEG-EPO
Isocyanate PEG, mPEG-ISC
Isothiocyanate PEG, mPEG-ITC
Maleimide PEG, mPEG-MAL
Ortho-pyridine disulfide PEG, mPEG-OPSS
Iodoacetyl PEG, mPEG-IA
Vinylsulfone PEG, mPEG-VS
PEG Biotin, mPEG-Biotin
Fluorescein PEG, mPEG-FITC
Rhodamine-PEG, mPEG-RB
Silane PEG, mPEG-Silane
Lipoic acid PEG, mPEG-LA
DSPE PEG, mPEG-DSPE
DMPE PEG, mPEG-DMPE
DPPE PEG, mPEG-DPPE
DLPE PEG, mPEG-DLPE
Cholesterol PEG, mPEG-CLS
DBCO PEG, mPEG-DBCO
 

Homobifunctional PEG產(chǎn)品目錄：
HO-PEG-OH
Amino PEG Amine, NH2-PEG-NH2
Thiol PEG Thiol, HS-PEG-HS
Carboxylic Acid PEG Acid, HOOC-PEG-COOH
Hydrazide-PEG-Hydrazide
Aldehyde PEG Aldehyde, CHO-PEG-CHO
Bifunctional NHS PEG, NHS-PEG-NHS
Bifunctional NPC PEG, NPC-PEG-NPC
Epoxide PEG Epoxide, EPO-PEG-EPO
Isocyanate PEG Isocyanate, ISC-PEG-ISC
Maleimide PEG Maleimide, MAL-PEG-MAL
OPSS-PEG-OPSS
PEG di-iodoacetate, IA-PEG-IA
Biotin-PEG-Biotin
PEG di-vinylsulfone, VS-PEG-VS
PEG di-acrylate, Acrylate-PEG-Acrylate
CDI-PEG-CDI
PFP-PEG-PFP, pentafluorophenyl PEG
 

Heterobifunctional PEG產(chǎn)品目錄：
Amino PEG Acid, NH2-PEG-COOH
Amino PEG hydroxyl, NH2-PEG-OH
Maleimide PEG NHS, MAL-PEG-NHS
Maleimide PEG PFP, MAL-PEG-PFP
Maleimide PEG Amine, MAL-PEG-NH2    
Maleimide PEG Acid, MAL-PEG-COOH
NHS-PEG-COOH 
NHS-PEG-OH
Biotin-PEG-NHS  
Biotin-PEG-NH2
Biotin-PEG-COOH      
Biotin-PEG-Maleimide
Biotin-PEG-FITC  
Biotin PEG Thiol, Biotin-PEG-SH
Thiol PEG Amine, HS-PEG-NH2
Thiol PEG Acid, HS-PEG-COOH
Thiol PEG OH, HS-PEG-OH      
Thiol PEG Azide, HS-PEG-N3
Thiol PEG Fluorescein, HS-PEG-FITC      
DSPE-PEG-NHS
DSPE-PEG-Maleimide, DSPE-PEG-MAL  
DSPE PEG Biotin
DSPE PEG Amine, DSPE-PEG-NH2  
DSPE PEG Acid, DSPE-PEG-COOH
Silane-PEG-Amine
Silane-PEG-COOH
Silane-PEG-Biotin
Silane-PEG-Maleimide
Silane-PEG-NHS  
Silane-PEG-SH
Azido PEG hydroxyl, N3-PEG-OH     
Azido PEG amine, N3-PEG-NH2
Azido PEG acid, N3-PEG-COOH
Azido PEG NHS, N3-PEG-NHS
Azido PEG Maleimide, N3-PEG-Mal  
Azido PEG Biotin, N3-PEG-Biotin
Fluorescein PEG NHS, FITC-PEG-NHS    
Fluorescein PEG Amine, FITC-PEG-NH2
Fluorescein PEG Maleimide, FITC-PEG-Mal     
Fmoc-NH-PEG-NHS
Fmoc-NH-PEG-NH2
Fmoc-NH-PEG-COOH
Boc-NH-PEG-NHS
Boc-NH-PEG-NH2
Boc-NH-PEG-COOH   
Acryloyl PEG COOH
Acryloyl PEG NHS      
Acryloyl PEG NH2
Alkyne PEG amine, Alkyne-PEG-NH2
Alkyne PEG acid, Alkyne-PEG-COOH
Alkyne PEG thiol, Alkyne-PEG-SH    
Alkyne PEG NHS, Alkyne-PEG-NHS
Alkyne PEG Maleimide, Alkyne-PEG-Mal 
Alkyne PEG Biotin, Alkyne-PEG-Biotin
 

Biotinylated PEGs產(chǎn)品列表：
PEG Biotin, mPEG-Biotin   
Biotin-PEG-NHS
Biotin-PEG-PFP   
Biotin-PEG-NH2
Biotin PEG hydrazide   
Biotin-PEG-COOH
Biotin-PEG-OH    
Biotin-PEG-Maleimide
Biotin-PEG-FITC  
Biotin-PEG-Biotin
Biotin-PEG-SH     
Other Fluorescent PEG Biotin
Folic Acid PEG Biotin  
 

Desthiobiotin-PEG-X
Iminobiotin-PEG-X

產(chǎn)品列表Surface Reactive PEGs：
Silane PEG, mPEG-Silane    
Silane-PEG-Amine
Silane-PEG-COOH      
Silane-PEG-Biotin
Silane-PEG-Maleimide 
Silane-PEG-NHS
Silane-PEG-SH     
Silane-PEG-OPSS
Silane-PEG-FITC
Silane-PEG-Acrylate
Silane-PEG-N3, Silane PEG Azide
Thiol PEG, methoxy PEG Thiol, mPEG-SH
Thiol PEG Amine, HS-PEG-NH2
Thiol PEG Acid, HS-PEG-COOH
Thiol PEG NHS, HS-PEG-NHS
Thiol PEG OH, HS-PEG-OH      
Thiol PEG Biotin, HS-PEG-Biotin
Thiol PEG Azide, HS-PEG-N3    
Thiol PEG Alkyne, HS-PEG-Alk
Thiol PEG Fluorescein, HS-PEG-FITC      
Lipoic acid PEG, mPEG-LA
Lipoic acid PEG amine, LA-PEG-NH2
Lipoic acid PEG acid, LA-PEG-COOH
Lipoic acid PEG NHS, LA-PEG-NHS 
Lipoic acid PEG, LA-PEG-Biotin
Lipoic acid PEG, LA-PEG-OH
Lipoic acid PEG, LA-PEG-FITC
Lipoic acid PEG, LA-PEG-NHS
Lipoic acid PEG, LA-PEG-MAL
 

Fluorescent PEGs產(chǎn)品目錄表：
Fluorescein PEG, mPEG-FITC    
Fluorescein PEG Amine, FITC-PEG-NH2
Fluorescein PEG hydroxyl, FITC-PEG-OH 
Fluorescein PEG acid, FITC-PEG-COOH
Fluorescein PEG Thiol, FITC-PEG-SH      
Fluorescein PEG Biotin, FITC-PEG-Biotin
Fluorescein PEG NHS, FITC-PEG-NHS    
Fluorescein PEG Azide, FITC-PEG-N3
Fluorescein PEG Maleimide, FITC-PEG-Mal     
Rhodamine-PEG, mPEG-RB
Rhodamine PEG hydroxyl, RB-PEG-OH    
Rhodamine PEG Amine, RB-PEG-NH2
Rhodamine PEG Thiol, RB-PEG-SH   
Rhodamine PEG Acid, RB-PEG-COOH
Rhodamine PEG Biotin, RB-PEG-Biotin    
Rhodamine-PEG-NHS,RB-PEG-NHS
Rhodamine-PEG-MAL,RB-PEG-MAL
Cy5 PEG Amine, Cy5-PEG-NH2 
Cy5 PEG NHS, Cy5-PEG-NHS
Cy5 PEG acid, Cy5-PEG-COOH 
Cy5 PEG Maleimide, Cy5-PEG-Mal
Cy5 PEG Thiol, Cy5-PEG-SH     
Cy5 PEG Biotin, CY5-PEG-Biotin
Cy5 PEG Folic acid, Cy5-PEG-FA     
Cy3 PEG Amine, Cy3-PEG-NH2 
Cy3 PEG NHS, Cy3-PEG-NHS
Cy3 PEG acid, Cy3-PEG-COOH 
Cy3 PEG Maleimide, Cy3-PEG-Mal
Cy3 PEG Thiol, Cy3-PEG-SH     
Cy3 PEG Biotin, Cy3-PEG-Biotin
Cy3 PEG Folic acid, Cy3-PEG-fa
Other Cy3 PEG Derivatives
 

Click PEG Derivatives產(chǎn)品目錄表：
mPEG-DBCO
DBCO PEG NHS, DBCO-PEG-NHS
DBCO PEG Maleimide, DBCO-PEG-MAL 
DBCO PEG Amine, DBCO-PEG-NH2
DBCO PEG acid, DBCO-PEG-COOH 
DBCO PEG DSPE
DBCO PEG Silane
DBCO PEG Biotin
DBCO PEG Flurorescein, DBCO-EPG-FITC     
DBCO PEG Cy3
DBCO PEG Cy5
 

Polymerizable PEGs產(chǎn)品目錄表：
Acrylate PEG, mPEG-ACR  
Methacrylate PEG, mPEG-MACR
Acrylate PEG NHS      
Acrylate PEG Maleimide
Acrylate PEG Biotin     
Acrylate PEG Amine, Acrylate-PEG-NH2
Acrylate PEG Acid, Acrylate-PEG-COOH  
Acrylate PEG Acrylate
 

Multiarm PEGs產(chǎn)品目錄表：
2 Arm/Branched PEG Acid    10000 Da      
2 Arm/Branched PEG Acid    4000 Da 
2 Arm/Branched PEG Amine 10000 Da      
2 Arm/Branched PEG Amine 4000 Da 
2 Arm/Branched PEG NHS   10000 Da      
2 Arm/Branched PEG NHS   4000 Da 
2 Arm/Branched PEG Maleimide  10000 Da      
2 Arm/Branched PEG Maleimide  4000 Da 
2 Arm/Branched PEG Biotin 10000 Da      
2 Arm/Branched PEG Biotin
4-Arm PEG Acrylate
4-Arm PEG Amine
4-Arm PEG Thiol
4-Arm PEG Maleimide 
4-Arm PEG NHS
4-Arm PEG Biotin
4 Arm PEG vinyl sulfone
8-Arm PEG Amine
8-Arm PEG Thiol
8-Arm PEG NHS  
8-Arm PEG Maleimide
8-Arm PEG Biotin
8 Arm PEG vinyl sulfone
 

Other PEG Reagents產(chǎn)品目錄表：
Folic Acid PEG, mPEG-FA   Folic
Acid PEG Amine, FA-PEG-NH2
Folic Acid PEG Acid, FA-PEG-COOH
Folic Acid PEG Thiol, FA-PEG-SH
Folic Acid PEG DSPE  
Folic Acid PEG NHS
Folic Acid PEG Maleimide   
Folic Acid PEG Biotin
Folic Acid PEG FITC   
Vitamin E PEG, mPEG alfa-tocopherol      
Vitamin E PEG, mPEG alfa-tocopherol      
Vitamin E PEG, mPEG alfa-tocopherol      
Vitamin E PEG NHS, Tocopherol PEG NHS     
Vitamin E PEG NHS, Tocopherol PEG NHS     
Vitamin E PEG NHS, Tocopherol PEG NHS     
Vitamin E PEG NH2, Tocopherol PEG amine    
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG NH2, Tocopherol PEG amine    
Vitamin E PEG Maleimide, Tocopherol PEG maleimide           
Vitamin E PEG Maleimide, Tocopherol PEG maleimide           
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D      
Vitamin D PEG, mPEG Vitamin D      
Vitamin D PEG, mPEG Vitamin D      
Vitamin D PEG, mPEG Vitamin D      
Vitamin D PEG NHS
Vitamin D PEG NHS
Vitamin D PEG NHS
Vitamin D PEG NH2
Vitamin D PEG NH2
Vitamin D PEG NH2
Vitamin D PEG Maleimide
Vitamin D PEG Maleimide   
Vitamin D PEG Maleimide
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid    
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid    
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid    
Retinoic acid PEG NHS
Retinoic acid PEG Biotin     
Retinoic acid PEG FITC
 

PEG amino acid/peptide Conjugates產(chǎn)品列表：
mPEG L-Lysine
mPEG L-Lysine    
Lysine PEG Lysine
4 Arm PEG L-Lysine
8 Arm PEG L-Lysine    
mPEG Cysteine
Cysteine PEG Cysteine
4 Arm PEG Cysteine
mPEG Glutathione
Glutathione PEG Glutathione
4 Arm PEG Glutathione
mPEG Aspartic Acid
Aspartic Acid PEG Aspartic Acid 
4 Arm PEG Aspartic Acid    
mPEG Glutamic Acid   
Glutamic Acid PEG Glutamic Acid
4 Arm PEG Glutamic Acid
PEG Metal Chelate Conjugates
mPEG DTPA 
DTPA PEG Biotin 
DTPA PEG FITC  
4A PEG DTPA      
mPEG NTA   
NTA PEG Biotin   
NTA PEG FITC    
4A PEG NTA
NTA PEG Biotin
NTA PEG Biotin          
BSA PEG Conjugate     
Polylysine PEG Conjugate   
Polylysine PEG Conjugate
Dextran PEG Conjugate
Dextran PEG Conjugate
Chymotrypsin PEG Conjugate
Superoxide Dimutase PEG
Lipase PEG          
PEG esterase