產品名稱：Anti-Mouse CD183 （CXCR3） Functional Grade Purified
貨號：eBioscience 16-1831-85
規格：500 ug
Anti-Mouse CD183 （CXCR3） Functional Grade Purified
Also known as: C-X-C chemokine receptor type 3, IP-10 receptor
Clone: CXCR3-173
Description: The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 （mig）, CXCL10 （IP-10）and CXCL11 （ITAC）. CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.
The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.