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由高純硅膠、嚴格控制的生產工藝和色譜柱裝填工藝所得，為色譜工作者提供、最重現的HPLC色譜柱。

詳細介紹

當化學家為制藥與生物制藥產品開發分析方法時，選擇具有重現能力的HPLC柱至關重要。被選擇的色譜柱需要在這個新的藥物產品的整個生命周期中都能提供一致的色譜分析結果，而Symmetry色譜柱顯示出跨越多年的重現性。確保重現性是我們在供應Symmetry色譜柱時的要素。如此優秀的重現性，則來自于我們持續不懈的致力于HPLC色譜柱行業內的指標控制。Symmetry色譜柱，由高純硅膠、嚴格控制的生產工藝和色譜柱裝填工藝所得，為色譜工作者提供、最重現的HPLC色譜柱。

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產品技術與性能，為硅膠基質的C18和C8色譜柱樹立了新的行業標準

■精心設計填料的物理和化學性質，以確保容載量與分辨率；尤其有利于在低至中等pH條件下分離純化可電離化合物。

■耐受低pH條件，鍵合相穩定牢固，柱壽命長。

■結合于OBD™制備柱設計，確保柱效與最長柱壽命。

■填料起始于有機硅合成，繼以技術的表面化學修飾，所有制造工藝與過程均依從cGMP規范，確保產品的高純品質、高優性能、與高度可靠。

This paper reports the validation of a liquid chromatography tandem mass spectrometry (LC-MS/MS) method that allows the quantification of 10 antiretroviral (ARV) drugs in peripheral blood mononuclear cells (PBMCs) using 6 different isotopic internal standards (IS) and its clinical application. PBMCs are isolated from blood by density gradient centrifugation and drugs are extracted with a 60% methanol (MeOH) solution containing the 6 IS. The cell extract is then injected in the HPLC system and analytes are separated on a Symmetry Shield RP18 2.1 mm × 50 mm column. The different molecules are then detected by MS/MS in electrospray positive or negative ionisation modes and data are recorded using the multiple reaction monitoring (MRM) mode. Calibration curves are constructed in the range of 0.25–125 ng/ml of cell extract by a 1/x2 weighted quadratic regression. The regression coefficients obtained are always greater than 0.99 and back calculated values always comprised in the range of ±15% from their nominal concentration. Mean extraction recoveries are greater than 80% for all analytes and the method is accurate and precise with CV and bias lower than 9.4%. The lower limits of quantification (LLOQ) of the different drugs range from 0.0125 to 0.2 ng/ml of cell extract. This method was successfully applied to a cohort of 98 HIV-infected patients treated with Kaletra®(400/100 mg of lopinavir/ritonavir (LPV/RTV) twice a day, n = 48) or with Stocrin® (600 mg once a day, n = 50) and has been tested for cellular quantification of tipranavir (TPV) in 2 patients treated with Aptivus®(500 mg twice a day). The patients treated by Kaletra® showed mean cell-associated concentrations (CC) of 1819.0 and 917.2 ng/ml, for LPV and RTV, respectively. Patients treated with Stocrin® showed mean CC of 2388.11 ng/ml while both patients under Aptivus® showed TPV CC of 4322.7 and 1078.0 ng/ml, respectively. This method can be used to analyze ARV drug concentrations within the target tissue.

品名	規格	編號
Symmetry C8 Column	100?, 5 µm, 4.6 mm X 250 mm, 1/pkg	186007715
Symmetry C8 Column	100?, 3.5 µm, 3 mm X 100 mm, 1/pkg	WAT054270
Symmetry C8 Column	100?, 3.5 µm, 3 mm X 150 mm, 1/pkg	186000698
Symmetry C8 Column	100?, 5 µm, 3 mm X 150 mm, 1/pkg	186000697
Symmetry C8 Column	100?, 3.5 µm, 4.6 mm X 50 mm, 1/pkg	WAT054230
Symmetry C8 Column	100?, 5 µm, 4.6 mm X 150 mm, 1/pkg	WAT200620
Symmetry C8 Column	100?, 3.5 µm, 4.6 mm X 30 mm, 1/pkg	WAT045995
Symmetry C8 Column	100?, 5 µm, 4.6 mm X 100 mm, 1/pkg	186002087
Symmetry C8 Column	100?, 3.5 µm, 2.1 mm X 50 mm, 1/pkg	186002083
Symmetry C8 Column	100?, 3.5 µm, 2.1 mm X 100 mm, 1/pkg	WAT200624
Symmetry C8 Column	100?, 5 µm, 3 mm X 250 mm, 1/pkg	WAT058961
Symmetry C8 Column	100?, 5 µm, 2.1 mm X 150 mm, 1/pkg	186000691
Symmetry C8 Column	100?, 3.5 µm, 2.1 mm X 30 mm, 1/pkg	WAT056955
Symmetry C8 Column	100?, 3.5 µm, 4.6 mm X 75 mm, 1/pkg	WAT058977
Symmetry C8 Column	100?, 5 µm, 2.1 mm X 50 mm, 1/pkg	WAT066200
Symmetry C8 Column	100?, 5 µm, 4.6 mm X 50 mm, 1/pkg	186000212
Symmetry C8 Column	100?, 5 µm, 2.1 mm X 100 mm, 1/pkg	WAT054245
Symmetry C8 Column	100?, 3.5 µm, 4.6 mm X 150 mm, 1/pkg	186002609
Symmetry C8 Column	100?, 3.5 µm, 2.1 mm X 150 mm, 1/pkg	WAT094237
Symmetry C8 Column	100?, 5 µm, 3.9 mm X 150 mm, 1/pkg	WAT106011
Symmetry C8 Column	100?, 3.5 µm, 4.6 mm X 100 mm, 1/pkg	WAT046970
Symmetry C8 Method Validation Kit	100?, 3.5 µm, 4.6 mm X 150 mm, 3/pkg	WAT200630
Symmetry C8 Method Validation Kit	100?, 5 µm, 3.9 mm X 150 mm, 3/pkg	186000712
Symmetry C8 Method Validation Kit	100?, 5 µm, 4.6 mm X 150 mm, 3/pkg	WAT066225
Symmetry C8 Method Validation Kit	100?, 5 µm, 4.6 mm X 250 mm, 3/pkg	186000238
Symmetry C8 Prep Column	100?, 7 µm, 19 mm X 300 mm, 1/pkg	WAT066204
Symmetry C8 Prep Column	100?, 5 µm, 19 mm X 100 mm, 1/pkg	WAT200661
Symmetry C8 Prep Column	100?, 5 µm, 7.8 mm X 50 mm, 1/pkg	WAT046955
Symmetry C8 Prep Column	100?, 5 µm, 7.8 mm X 100 mm, 1/pkg	186000214
Symmetry C8 Prep Column	100?, 7 µm, 7.8 mm X 300 mm, 1/pkg	186000215
Symmetry C8 Prep Column	100?, 5 µm, 30 mm X 100 mm, 1/pkg	WAT054435
Symmetry C8 Prep Column	100?, 5 µm, 30 mm X 50 mm, 1/pkg	186007733
Symmetry C8 Prep Column	100?, 7 µm, 7.8 mm X 150 mm, 1/pkg	186007737
Symmetry C8 Prep Column	100?, 7 µm, 19 mm X 150 mm, 1/pkg	186007739