MLH1 Monoclonal Antibody detects endogenous levels of MLH1 protein.

Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]