Description: The human IFN-gamma ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human IFN-gamma. The human IFN-gamma ELISA is for research use only. Not for diagnostic or therapeutic procedures.
This ELISA kit contains improved antibodies for even better sensitivity.
IFN-gamma, also called Type II interferon, is a homodimeric gycoprotein containing approximay 21 to 24 kD subunits.In contrast to IFN-gamma and IFN-gamma synthesis, which can occur in any cell, production of IFN-gamma is a function of T cells and NK cells.
Type II IFN or IFN-gamma is a lymphokine that displays no molecular homology with type I IFN, but shares some important biologic activities. Specifically, IFN induces an anti-viral state and is anti-proliferative. In addition, IFN-gamma has several properties related to immunoregulation.
（1） IFN- is a potent activator of mononuclear phagocytes, e.g. IFN-gamma stimulates the expression of Mac-1, augments endocytosis and phagocytosis by monocytes; and activates macrophages to kill tumor cells by releasing reactive oxagen intermediates and TNF-alpha.
（2） IFN-gamma induces or augments the expression of MHC antigens on macrophages, T and B cells and some tumor cell lines.
（3） On T and B cells IFN- promotes differentiation. It enhaces proliferation of activated B cells and can act synergistically with IL-2 to increase immunoglobulin light-chain synthesis. IFN-gamma is one of the natural B-cell differentiation factors.
（4） Finally, IFN-gamma activates neutrophils, NK cells and vascular endothelial cells.The role of IFN-gamma as a disease marker has been demonstrated for a number of different pathological situations.
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