當前位置：廈門慧嘉生物科技有限公司>>細胞因子>>Prospec >>OPG Fc Human/ 重組人護骨素Fc 產(chǎn)品編號：CYT-266

OPG Fc Human/ 重組人護骨素Fc 產(chǎn)品編號：CYT-266

返回列表頁

參考價

面議

具體成交價以合同協(xié)議為準

產(chǎn)品型號

品牌

廠商性質(zhì)代理商

所在地廈門市

在線詢價收藏產(chǎn)品查看聯(lián)系電話

聯(lián)系方式：陳先生查看聯(lián)系方式

更新時間：2016-01-18 02:39:00瀏覽次數(shù)：531次

聯(lián)系我時，請告知來自環(huán)保在線

產(chǎn)品分類 品牌分類

  細胞因子

Prospec

全部產(chǎn)品列表

暫無信息

廈門慧嘉生物科技有限公司

經(jīng)營模式：代理商

商鋪產(chǎn)品：9325條

所在地區(qū)：福建廈門市

聯(lián)系人：陳先生

詢價 給他留言

產(chǎn)品簡介

OPG Fc Human/ 重組人護骨素Fc 產(chǎn)品編號：CYT-266
產(chǎn)品規(guī)格：10μg/50μg/1mg

詳細介紹

OPG Fc Human/ 重組人護骨素Fc

產(chǎn)品編號：CYT-266
產(chǎn)品規(guī)格：10μg/50μg/1mg

Synonyms	TNFRSF11B, OPG, OCIF, Osteoclastogenesis inhibitory factor, TR1, MGC29565.
Introduction	Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis.
Description	Recombinant OPG produced in yeast contains 412 amino acid residues, including 180 residues from mature OPG （a.a 22-201） and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 46.5 kDa. As a result of glycosylation, the recombinant Osteoprotegrin migrates as a 49 kDa protein in SDS-PAGE under reducing conditions. The OPG is purified by proprietary chromatographic techniques.
Amino Acid Sequence	AA Sequence: OPG 22-201: ETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYY TDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCL KHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCS VFGLLLTQKGNATHDNICSGNSESTQKCGIDVTL.
Fc232	: EPKSSDKTHTCPPCPAPEFEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDV SHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLN GKEYKCKVSNKALPTPIEKTISKAKGQREPQVYTLPPSRDELTKNQVSLTC LVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRW GNVFSCSVMHEALHNHYTQKSLSLSPGK.
Source	Pichia Pastoris.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	OPG was lyophilized from a 0.2μm filtered concentrated （0.5mg/ml） solution in PBS, pH= 7.4.
Solubility	It is recommended to reconstitute the lyophilized Osteoprotegerin in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Osteoprotegerin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution OCIF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 90.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Biological Activity	Determined by its ability to neutralize the stimulation of U937 cells treated with 10ng/ml of soluble RANKL （sRANKL）.
Usage	Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.